Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 9/20 | 0.43 |
| ▸ | PIP4K2C | Q8TBX8 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10972213 | 0.81 | RAB9A (0.52) | SMN1; SMN2RAB9AALDH1A1HSD17B10NPC1 | |
| SCHEMBL8044019 | 0.80 | KMT2A (0.40) | SMN1; SMN2RAB9AALDH1A1HSD17B10MAPT | |
| SCHEMBL8032361 | 0.80 | ALDH1A1 (0.47) | SMN1; SMN2RAB9AHTTALDH1A1NPC1 | |
| SCHEMBL8032325 | 0.80 | SMN1; SMN2 (0.36) | SMN1; SMN2RAB9AALDH1A1NPC1MAPT | |
| SCHEMBL8051723 | 0.80 | ALDH1A1 (0.37) | SMN1; SMN2RAB9AALDH1A1NPC1MEN1 | |
| SCHEMBL8042823 | 0.78 | ALDH1A1 (0.44) | SMN1; SMN2RAB9AHTTALDH1A1MAPT | |
| SCHEMBL8043945 | 0.76 | ALDH1A1 (0.57) | SMN1; SMN2HTTALDH1A1HSD17B10TP53 | |
| SCHEMBL8051391 | 0.76 | UBE2M (0.51) | SMN1; SMN2RAB9AHTTPIP4K2CALDH1A1 | |
| SCHEMBL8043987 | 0.75 | ALDH1A1 (0.45) | SMN1; SMN2RAB9AALDH1A1HSD17B10NPC1 | |
| SCHEMBL8042045 | 0.75 | UBE2M (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |