Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8034370 | 0.81 | MEN1 (0.37) | MEN1KMT2ARAB9ANPC1POLB | |
| SCHEMBL8033951 | 0.77 | HTR1A (0.46) | MEN1KMT2ARAB9ANPC1LMNA | |
| SCHEMBL8045340 | 0.76 | KDM4E (0.63) | MEN1KMT2ARAB9ANPC1LMNA | |
| SCHEMBL8043006 | 0.75 | RAB9A (0.43) | MEN1KMT2ARAB9ANPC1POLB | |
| SCHEMBL8042838 | 0.75 | SMN1; SMN2 (0.50) | MEN1KMT2ARAB9ANPC1POLB | |
| SCHEMBL8044648 | 0.75 | HSD17B10 (0.50) | MEN1KMT2ARAB9ANPC1POLB | |
| SCHEMBL8050096 | 0.71 | RAB9A (0.37) | MEN1KMT2ARAB9ANPC1POLB | |
| SCHEMBL8042763 | 0.70 | CDK1 (0.31) | LMNA | |
| SCHEMBL8044019 | 0.69 | KMT2A (0.40) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL8042817 | 0.69 | ALDH1A1 (0.50) | MEN1KMT2ARAB9ANPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |