Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | LMNA | P02545 | 6/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044646 | 0.91 | ALDH1A1 (0.52) | MAPTALDH1A1LMNARAB9ANPC1 | |
| SCHEMBL8046481 | 0.89 | ALDH1A1 (0.44) | MAPTALDH1A1LMNARAB9ANPC1 | |
| SCHEMBL8043688 | 0.88 | HTR1A (0.46) | MAPTALDH1A1LMNARAB9ANPC1 | |
| SCHEMBL8046147 | 0.85 | ALDH1A1 (0.42) | MAPTALDH1A1LMNARAB9ANPC1 | |
| SCHEMBL8044036 | 0.84 | KMT2A (0.44) | MAPTALDH1A1LMNARAB9ANPC1 | |
| SCHEMBL8050040 | 0.84 | HTT (0.51) | MAPTALDH1A1LMNARAB9ANPC1 | |
| SCHEMBL8032462 | 0.83 | CYP2C19 (0.39) | MAPTALDH1A1LMNARAB9ANPC1 | |
| SCHEMBL8042704 | 0.83 | DCUN1D1 (0.44) | MAPTALDH1A1LMNARAB9ANPC1 | |
| SCHEMBL8045832 | 0.82 | LMNA (0.42) | MAPTALDH1A1LMNARAB9ANPC1 | |
| SCHEMBL8042146 | 0.82 | KDM4E (0.42) | MAPTLMNARAB9ANPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |