Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042846 | 0.83 | HSD17B10 (0.40) | GABRA5GABRB2HSD17B10GAAMAPT | |
| SCHEMBL8031825 | 0.80 | LMNA (0.40) | RXRARXRBRXRGHSD17B10GAA | |
| SCHEMBL8043598 | 0.79 | RECQL (0.55) | HSD17B10MAPTALDH1A1NPSR1 | |
| SCHEMBL8034024 | 0.78 | HTR1A (0.41) | MAPTNPC1ALDH1A1NFKB1RAB9A | |
| SCHEMBL8033946 | 0.78 | ATM (0.45) | NPC1ALDH1A1RAB9APOLB | |
| SCHEMBL8050649 | 0.78 | RECQL (0.37) | RXRARXRBRXRGHSD17B10GAA | |
| SCHEMBL8044583 | 0.78 | HSD17B10 (0.50) | RXRARXRBRXRGHSD17B10MAPT | |
| SCHEMBL8046541 | 0.76 | KDM4E (0.47) | GAAMAPTALDH1A1RAB9A | |
| SCHEMBL8042821 | 0.76 | RPA1 (0.54) | HSD17B10ALDH1A1NPSR1 | |
| SCHEMBL8032480 | 0.76 | PKM (0.38) | RXRARXRBRXRGMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |