Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044080 | 0.92 | ALDH1A1 (0.40) | HTTCYP2C19ALDH1A1KMT2AMEN1 | |
| SCHEMBL8044897 | 0.87 | ALDH1A1 (0.45) | HTTCYP2C19ALDH1A1KMT2AMEN1 | |
| SCHEMBL8043225 | 0.86 | DCUN1D1 (0.39) | — | |
| SCHEMBL8045080 | 0.83 | LMNA (0.31) | KMT2ALMNA | |
| SCHEMBL8033250 | 0.81 | HTT (0.41) | HTTCYP2C19ALDH1A1KMT2AMEN1 | |
| SCHEMBL8033764 | 0.81 | HTT (0.46) | HTTCYP2C19ALDH1A1KMT2AMEN1 | |
| SCHEMBL8043339 | 0.80 | NPC1 (0.52) | HTTCYP2C19ALDH1A1KMT2AMEN1 | |
| SCHEMBL8032709 | 0.79 | HTT (0.41) | HTTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL8033672 | 0.79 | NPSR1 (0.39) | HTTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL8051020 | 0.77 | KDM4C (0.38) | HTTALDH1A1KMT2AMEN1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |