SCHEMBL8046353

SCHEMBL8046353

CCn1nnc(Sc2nc(Br)c(Br)s2)n1

nearest known ligand 0.31

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TRPM8 Q7Z2W7 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8050184 0.89 NPC1 (0.32)
SCHEMBL8033591 0.80
SCHEMBL8045500 0.77
SCHEMBL8041981 0.73 FBP1 (0.50)
SCHEMBL8047429 0.73 ALDH1A1 (0.30)
SCHEMBL8042707 0.71 ALDH1A1 (0.46)
SCHEMBL8042548 0.70 TRPM8 (0.34) TRPM8
SCHEMBL8033176 0.69 HSP90AA1 (0.44) TRPM8
SCHEMBL8048046 0.67 MAPT (0.47) TRPM8
SCHEMBL8045845 0.66 TRPM8 (0.32) TRPM8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6080772-A 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY SUGEN, INC. (US) 2000-06-27 US disclosed