Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | USP8 | P40818 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8034180 | 0.89 | MAPT (0.49) | EP300KEAP1NFE2L2MEN1KMT2A | |
| SCHEMBL8043200 | 0.86 | ALDH1A1 (0.43) | KMT2AALDH1A1HPGDHTTMAPT | |
| SCHEMBL8043931 | 0.85 | PTGS2 (0.43) | — | |
| SCHEMBL8033669 | 0.84 | KDM1A (0.51) | EP300KEAP1NFE2L2MEN1KMT2A | |
| SCHEMBL8037043 | 0.82 | SMN1; SMN2 (0.39) | MEN1KMT2AALDH1A1HPGDHTT | |
| SCHEMBL8043968 | 0.81 | MEN1 (0.45) | EP300MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL8032354 | 0.80 | ALDH1A1 (0.46) | EP300KEAP1NFE2L2MEN1KMT2A | |
| SCHEMBL8043905 | 0.80 | KDM4E (0.37) | MEN1KMT2AALDH1A1HTTMAPT | |
| SCHEMBL8050838 | 0.79 | KDM4E (0.36) | MEN1KMT2AALDH1A1HPGDHTT | |
| SCHEMBL8033936 | 0.78 | ALDH1A1 (0.42) | MEN1KMT2AALDH1A1HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |