Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | EIF4E | P06730 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043200 | 0.88 | ALDH1A1 (0.43) | KMT2AALDH1A1KDM4EHPGDPOLB | |
| SCHEMBL8043905 | 0.86 | KDM4E (0.37) | MEN1KMT2AALDH1A1KDM4EMAPK1 | |
| SCHEMBL8045514 | 0.85 | HPGD (0.54) | MEN1KMT2AALDH1A1KDM4ERECQL | |
| SCHEMBL8050838 | 0.84 | KDM4E (0.36) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL8037043 | 0.84 | SMN1; SMN2 (0.39) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL8043931 | 0.84 | PTGS2 (0.43) | — | |
| SCHEMBL8047017 | 0.83 | HSP90AA1 (0.44) | MEN1KMT2AALDH1A1KDM4ERECQL | |
| SCHEMBL8043941 | 0.83 | PTGS2 (0.37) | MEN1KMT2AALDH1A1KDM4EPOLB | |
| SCHEMBL8044888 | 0.82 | MEN1 (0.53) | MEN1KMT2AALDH1A1KDM4ERECQL | |
| SCHEMBL8033936 | 0.82 | ALDH1A1 (0.42) | MEN1KMT2AALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |