Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 2/20 | 0.35 |
| ▸ | PPIA | P62937 | 1/20 | 0.35 |
| ▸ | PPID | Q08752 | 1/20 | 0.35 |
| ▸ | PPIL1 | Q9Y3C6 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | DRD3 | P35462 | 2/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.32 |
| ▸ | MLNR | O43193 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8052477 | 0.79 | PIN1 (0.37) | PIN1PPIAPPIDPPIL1CYP1A2 | |
| SCHEMBL28611722 | 0.77 | NFKB1 (0.38) | CYP1A2CYP2D6ATMTDP1 | |
| SCHEMBL8045648 | 0.77 | L3MBTL1 (0.35) | — | |
| SCHEMBL27347850 | 0.76 | RAB9A (0.35) | PIN1PPIAPPIDPPIL1EPAS1 | |
| SCHEMBL7202944 | 0.76 | MLNR (0.35) | GRM2SLC6A4DRD3OPRK1HTR2B | |
| SCHEMBL16658443 | 0.73 | GPR35 (0.39) | CYP1A2CYP2D6MAPK1TDP1 | |
| SCHEMBL6634968 | 0.71 | PARP1 (0.51) | PIN1PPIAPPIDPPIL1CYP1A2 | |
| SCHEMBL29739713 | 0.71 | PARP1 (0.51) | PIN1PPIAPPIDPPIL1CYP1A2 | |
| SCHEMBL8046730 | 0.71 | MLNR (0.32) | GRM2SLC6A4DRD3OPRK1HTR2B | |
| SCHEMBL15667116 | 0.70 | GPR35 (0.42) | CYP1A2ADRA2ATDP1PNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6100268-A | MIGRAINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2000-08-08 | — | — | US | disclosed |
| CN-1052006-C | Dihydrobenzopyran derivatives as vasoconstrictors, preparation and use thereof | JANSSEN PHARMACEUTICA NV (NL) | 2000-05-03 | — | — | CN | disclosed |
| US-5824682-A | Vasoconstrictive dihydrobenzopyran derivatives | JANSSEN PHARMACEUTICA, N.V. (BE) | 1998-10-20 | — | — | US | disclosed |
| CN-1129451-A | Dihydrobenzopyran derivatives as vasoconstrictors | JANSSEN PHARMACEUTICA NV (BE) | 1996-08-21 | — | — | CN | disclosed |
| EP-0714396-A1 | VASOCONTRICTIVE DIHYDROBENZOPYRAN DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-06-05 | — | — | EP | disclosed |
| WO-1995005383-A1 | VASOCONTRICTIVE DIHYDROBENZOPYRAN DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-02-23 | — | — | WO | disclosed |