Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | CCNC | P24863 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3831380 | 0.80 | KDM4E (0.67) | KDM4EMEN1KMT2ANPC1GAA | |
| SCHEMBL460799 | 0.79 | KDM4E (0.65) | KDM4EMEN1KMT2ANPC1GAA | |
| SCHEMBL3829254 | 0.79 | KDM4E (1.00) | KDM4EMEN1KMT2AGAANOTUM | |
| SCHEMBL8045495 | 0.79 | HDAC1 (0.46) | KDM4EMEN1KMT2ANPC1GAA | |
| SCHEMBL8043317 | 0.79 | HSD17B1 (0.76) | RAB9AHSD17B1HSD17B2SMN1; SMN2 | |
| SCHEMBL8042130 | 0.79 | HSD17B1 (0.46) | KDM4EMEN1KMT2ANPC1RAB9A | |
| SCHEMBL11025151 | 0.79 | KDM4E (0.49) | KDM4EMEN1KMT2ANPC1GAA | |
| SCHEMBL8044729 | 0.77 | SMN1; SMN2 (0.43) | KDM4EMEN1KMT2ANPC1GAA | |
| SCHEMBL969040 | 0.77 | ALDH1A1 (0.52) | KDM4EMEN1KMT2ANPC1GAA | |
| SCHEMBL10138519 | 0.75 | HSD17B1 (0.42) | KDM4EMEN1KMT2ANPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |