Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 7/20 | 0.59 |
| ▸ | NPC1 | O15118 | 6/20 | 0.59 |
| ▸ | LMNA | P02545 | 6/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13064219 | 0.86 | RAB9A (0.60) | MAPTALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL12323120 | 0.84 | RAB9A (0.62) | MAPTALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL19566850 | 0.84 | RAB9A (0.49) | MAPTALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL22825216 | 0.83 | ADRB3 (0.45) | MAPTALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL9195091 | 0.82 | LTA4H (0.58) | MAPTALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL7185130 | 0.82 | ALDH1A1 (0.45) | MAPTALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL2220623 | 0.82 | LOXL2 (0.51) | MAPTALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL2515676 | 0.82 | RAB9A (0.58) | MAPTALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL12432986 | 0.82 | ALDH1A1 (0.60) | MAPTALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL201471 | 0.82 | MEN1 (0.65) | MAPTALDH1A1MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071652-A1 | Novel Piperazines, Pharmaceutical Compositions and Methods of Use Thereof | CORNERSTONE THERAPEUTICS, INC. (US) | 2012-03-22 | — | — | US | disclosed |
| US-8026195-B2 | Fungicidal N-cycloalkyl-carboxamide derivatives | BAYER CROPSCIENCE AG (DE) | 2011-09-27 | — | — | US | disclosed |
| US-7943622-B2 | Piperazines, pharmaceutical compositions and methods of use thereof | CORNERSTONE THERAPEUTICS, INC. (US) | 2011-05-17 | — | — | US | disclosed |
| US-20090326016-A1 | FUNGICIDAL N-CYCLOALKYL-CARBOXAMIDE DERIVATIVES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2009-12-31 | — | — | US | disclosed |
| US-20080051415-A1 | Novel piperazines, pharmaceutical compositions and methods of use thereof | THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH | 2008-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071652-A1 | Novel Piperazines, Pharmaceutical Compositions and Methods of Use Thereof | CHRNA7, CHRNA5, CHRNA2 | MAPT 2141/4885ALDH1A1 1032/4885MEN1 4856/4885 |
| US-20090326016-A1 | FUNGICIDAL N-CYCLOALKYL-CARBOXAMIDE DERIVATIVES | CBR3, CBR1, CYCS | MAPT 3996/4885ALDH1A1 1961/4885MEN1 4121/4885 |
| US-20080051415-A1 | Novel piperazines, pharmaceutical compositions and methods of use thereof | CHRNA7, CHRNA5, CHRNA2 | MAPT 2141/4885ALDH1A1 1032/4885MEN1 4856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.