Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8033660 | 0.92 | MAPT (0.44) | HTR1AHTR7HTR2ASMN1; SMN2RAB9A | |
| SCHEMBL8034019 | 0.87 | HPGD (0.36) | HTR1AHTR7HTR2ASMN1; SMN2RAB9A | |
| SCHEMBL8048230 | 0.87 | KDM4E (0.43) | SMN1; SMN2RAB9ANPC1TSHRLMNA | |
| SCHEMBL8043767 | 0.86 | KDM4E (0.49) | SMN1; SMN2RAB9ANPC1TSHRLMNA | |
| SCHEMBL8041907 | 0.84 | RAB9A (0.47) | SMN1; SMN2RAB9ANPC1TSHRLMNA | |
| SCHEMBL8050920 | 0.83 | RAB9A (0.39) | SMN1; SMN2RAB9ANPC1TSHRLMNA | |
| SCHEMBL8043400 | 0.82 | ALDH1A1 (0.53) | HTR1AHTR7HTR2ASMN1; SMN2RAB9A | |
| SCHEMBL8048106 | 0.82 | KDM4E (0.56) | SMN1; SMN2RAB9ANPC1TSHRLMNA | |
| SCHEMBL8048032 | 0.82 | RECQL (0.41) | SMN1; SMN2RAB9ANPC1TSHRKDM4E | |
| SCHEMBL8044774 | 0.81 | KDM4E (0.43) | HTR7SMN1; SMN2RAB9ANPC1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |