Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 9/20 | 0.37 |
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042531 | 0.86 | ALDH1A1 (0.47) | ALDH1A1RAB9ALMNATSHRHTT | |
| SCHEMBL8044096 | 0.84 | LMNA (0.45) | ALDH1A1RAB9ALMNATSHRHTT | |
| SCHEMBL8042735 | 0.81 | ALDH1A1 (0.44) | ALDH1A1RAB9ALMNATSHRHTT | |
| SCHEMBL8046275 | 0.80 | ALDH1A1 (0.42) | ALDH1A1RAB9ALMNATSHRHTT | |
| SCHEMBL8043331 | 0.80 | MAPT (0.34) | ALDH1A1LMNAHTTMAPK1TP53 | |
| SCHEMBL8043200 | 0.80 | ALDH1A1 (0.43) | ALDH1A1LMNATSHRHTTMAPK1 | |
| SCHEMBL8050838 | 0.78 | KDM4E (0.36) | ALDH1A1LMNATSHRHTTMAPK1 | |
| SCHEMBL8041803 | 0.78 | MAPT (0.34) | LMNAHTTMAPTMEN1KMT2A | |
| SCHEMBL8033936 | 0.78 | ALDH1A1 (0.42) | ALDH1A1LMNATSHRHTTMAPK1 | |
| SCHEMBL8046536 | 0.78 | KDM4E (0.33) | HTTMAPTPAX8PIP4K2CKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |