Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | USP5 | P45974 | 1/20 | 0.43 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3231863 | 0.86 | PTGS2 (0.44) | GAAKDM4EABCB11PTGS2LMNA | |
| SCHEMBL8336761 | 0.83 | GRM5 (0.39) | KDM4EAGBL2ABCB11PTGS2MEN1 | |
| SCHEMBL8338116 | 0.77 | ALOX15 (0.51) | ABCB11PTGS2MAPTMEN1KMT2A | |
| SCHEMBL9724259 | 0.73 | ALDH1A1 (0.43) | GAALMNASMN1; SMN2MAPTMEN1 | |
| SCHEMBL3992020 | 0.71 | ALDH1A1 (0.41) | KDM4ECYP2C9LMNASMN1; SMN2MAPT | |
| SCHEMBL1148332 | 0.68 | CNR1 (0.58) | KDM4EUSP5CYP2C9CNR1CNR2 | |
| SCHEMBL1127930 | 0.67 | CNR1 (0.54) | KDM4EUSP5CYP2C9PTGS2CNR1 | |
| SCHEMBL8053588 | 0.67 | USP5 (0.57) | GAAKDM4EUSP5AGBL2CYP2C9 | |
| SCHEMBL11452308 | 0.66 | CXCL8 (0.44) | GAAKDM4EPTGS2LMNASMN1; SMN2 | |
| SCHEMBL50522 | 0.65 | ALDH1A1 (0.61) | KDM4EUSP5CYP2C9PTGS2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6160003-A | 1,3,6-trihydro-6-aza-3-oxapentalen-2-one derivatives for the treatment of neoplasia | CELL PATHWAYS, INC. (US) | 2000-12-12 | — | — | US | disclosed |