SCHEMBL8057750

SCHEMBL8057750

Cc1ccccc1NC(=O)c1ccc(C2(F)CC2c2ccc(OC(F)(F)F)cc2)cc1

nearest known ligand 0.49

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 3/20 0.44
NPC1 O15118 2/20 0.44
POLB P06746 1/20 0.43
HPGD P15428 1/20 0.43
TRPV1 Q8NER1 5/20 0.43
KDM4E B2RXH2 1/20 0.43
NAMPT P43490 1/20 0.43
IGF2BP2 Q9Y6M1 1/20 0.41
GAA P10253 1/20 0.41
LIPE Q05469 1/20 0.40
MTOR P42345 1/20 0.39
F10 P00742 1/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
LMNA P02545 1/20 0.39
MAPK1 P28482 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8040665 0.86 POLB (0.56) RAB9ANPC1POLBHPGDKDM4E
SCHEMBL8038470 0.85 POLB (0.48) RAB9ANPC1POLBHPGDMEN1
SCHEMBL8057747 0.80 LMNA (0.49) RAB9ANPC1POLBHPGDKDM4E
SCHEMBL8038471 0.80 NPC1 (0.46) RAB9ANPC1POLBHPGDKDM4E
SCHEMBL8057743 0.79 LMNA (0.47) RAB9ANPC1POLBHPGDKDM4E
SCHEMBL6676510 0.69 IGF2BP2 (0.62) RAB9ANPC1POLBHPGDTRPV1
SCHEMBL28400205 0.69 KMT2A (0.58) RAB9ANPC1TRPV1NAMPTIGF2BP2
SCHEMBL8042055 0.69 S1PR4 (0.40) KDM4ENAMPT
SCHEMBL9055150 0.69 HPGD (0.89) RAB9ANPC1POLBHPGDKDM4E
SCHEMBL8057744 0.68 ALDH1A1 (0.36) RAB9ANPC1GAAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0805795-A1 NOVEL AROMATIC AMIDES, METHOD FOR PREPARING AND COMPOSITIONS CONTAINING SAME, AND USE THEREOF AS PESTICIDES Hoechst Schering AgrEvo S.A. (FR) 1997-11-12 EP claimed
WO-1996022965-A1 NOVEL AROMATIC AMIDES, METHOD FOR PREPARING AND COMPOSITIONS CONTAINING SAME, AND USE THEREOF AS PESTICIDES HOECHST SCHERING AGREVO S.A. (FR) 1996-08-01 WO claimed
US-6013837-A E.G.,4-(2-(3,4,5-TRICHLORO PHENYL) 1-FLUOROCYCLOPROPYL)-N-(2-METHYL PHENYL)BENZAMIDE; PARTICULAR USE AGAINST ARTHROPODS, HELMINTHS AND MOLLUSCS; INSECTICIDES; ACARICIDES; NEMATICIDES; PHOTOSTABILITY; NONTOXIC TO MAMMALS HOECHST MARION ROUSSEL (FR) 2000-01-11 US disclosed
WO-1996022965-A1 NOVEL AROMATIC AMIDES, METHOD FOR PREPARING AND COMPOSITIONS CONTAINING SAME, AND USE THEREOF AS PESTICIDES HOECHST SCHERING AGREVO S.A. (FR) 1996-08-01 WO disclosed