Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8059176 | 0.77 | OPRM1 (0.38) | HPGDCYP2C19POLBTDP1SMN1; SMN2 | |
| SCHEMBL8058487 | 0.76 | FDPS (0.46) | LMNAPOLBSMN1; SMN2CYP3A4ALDH1A1 | |
| SCHEMBL28823525 | 0.75 | CYP2C19 (0.45) | HPGDLMNARAB9ACYP2C19POLB | |
| SCHEMBL28013234 | 0.72 | RIPK1 (0.43) | HPGDLMNARAB9ACYP2C19POLB | |
| SCHEMBL8059181 | 0.72 | FDPS (0.52) | LMNARAB9ACYP2C19POLBSMN1; SMN2 | |
| SCHEMBL4485884 | 0.71 | RIPK1 (0.50) | HPGDLMNARAB9ACYP2C19POLB | |
| SCHEMBL28135655 | 0.71 | CYP2C19 (0.50) | HPGDLMNARAB9ACYP2C19POLB | |
| SCHEMBL8059117 | 0.70 | FDPS (0.58) | LMNACYP2C19CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL28997198 | 0.70 | CYP2C19 (0.53) | HPGDLMNARAB9ACYP2C19POLB | |
| SCHEMBL28040029 | 0.70 | KMT2A (0.46) | HPGDLMNARAB9ACYP2C19POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046180-A | NAALADase inhibitors | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-04 | — | — | US | disclosed |
| EP-0936914-A4 | — | — | 1999-08-25 | — | — | EP | disclosed |
| EP-0936914-A1 | HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-08-25 | — | — | EP | disclosed |
| WO-1997048400-A1 | HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1997-12-24 | — | — | WO | disclosed |