Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | ALPI | P09923 | 1/20 | 0.40 |
| ▸ | ALPG | P10696 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8059117 | 0.85 | FDPS (0.58) | FDPSHTTALDH1A1MAPTCYP3A4 | |
| SCHEMBL8059181 | 0.79 | FDPS (0.52) | FDPSHTTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL8059176 | 0.78 | OPRM1 (0.38) | FDPSSMN1; SMN2MAPTPOLB | |
| SCHEMBL8058488 | 0.76 | HPGD (0.41) | SMN1; SMN2ALDH1A1CYP3A4LMNAPOLB | |
| SCHEMBL8046493 | 0.72 | FDPS (0.55) | FDPSHTTALDH1A1MAPTCYP3A4 | |
| SCHEMBL8058433 | 0.70 | FDPS (0.53) | FDPSHTTALDH1A1MAPTCYP3A4 | |
| SCHEMBL8046734 | 0.69 | KDM4E (0.47) | SMN1; SMN2ALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL8061716 | 0.69 | MTNR1A (0.43) | MAPK1SMN1; SMN2GAAALDH1A1MAPT | |
| SCHEMBL8057314 | 0.68 | DHPS (0.39) | SMN1; SMN2ALDH1A1MAPTKDM4EMAPK14 | |
| SCHEMBL8046670 | 0.68 | KCNA5 (0.39) | FDPSHTTSMN1; SMN2ALPLALPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046180-A | NAALADase inhibitors | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-04 | — | — | US | disclosed |
| EP-0936914-A4 | — | — | 1999-08-25 | — | — | EP | disclosed |
| EP-0936914-A1 | HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-08-25 | — | — | EP | disclosed |
| WO-1997048400-A1 | HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1997-12-24 | — | — | WO | disclosed |