Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 5/20 | 0.40 |
| ▸ | LPAR5 | Q9H1C0 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | BMP1 | P13497 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8070525 | 0.89 | CYP1A2 (0.40) | LMNABMP1HRH3POLBALDH1A1 | |
| SCHEMBL8074945 | 0.83 | F10 (0.35) | THRATHRBLMNABMP1HRH3 | |
| SCHEMBL9043010 | 0.81 | KDM4E (0.47) | THRATHRBLMNAALDH1A1 | |
| SCHEMBL8075422 | 0.81 | PKM (0.48) | THRATHRBLPAR1LPAR5KMT2A | |
| Hydrochloric Acid SCHEMBL8070153 | 0.80 | PKM (0.47) | THRATHRBLPAR1LPAR5KMT2A | |
| SCHEMBL27210019 | 0.74 | LPAR1 (0.59) | LPAR1LPAR5HRH3LTA4H | |
| SCHEMBL8070527 | 0.73 | PKM (0.54) | LPAR1LPAR5KMT2AMEN1POLB | |
| SCHEMBL8068481 | 0.72 | THRA (0.43) | THRATHRBLPAR1LPAR5KMT2A | |
| SCHEMBL8068578 | 0.72 | LPAR1 (0.43) | THRATHRBLPAR1LPAR5BMP1 | |
| SCHEMBL8068838 | 0.72 | ALDH1A1 (0.41) | THRATHRBLPAR1LPAR5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057322-A | USEFUL IN TREATMENT OF CARDIOVASCULAR DISEASES | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-05-02 | — | — | US | disclosed |
| EP-0723956-B1 | Basically substituted benzoylguanidines, process for their preparation, their use as medicaments or diagnostics as well as medicaments containing them | HOECHST AG (DE) | 1999-10-13 | — | — | EP | disclosed |
| EP-0723956-A1 | Basically substituted benzoylguanidines, process for their preparation, their use as medicaments or diagnostics as well as medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-07-31 | — | — | EP | disclosed |