Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8068363 | 0.88 | HCRTR1 (0.41) | ALDH1A1KMT2A | |
| SCHEMBL8064770 | 0.82 | ALDH1A1 (0.40) | ALDH1A1KMT2A | |
| SCHEMBL8064982 | 0.81 | HSD11B1 (0.45) | HSD11B1 | |
| SCHEMBL8060221 | 0.80 | HTR1A (0.43) | — | |
| SCHEMBL8066441 | 0.80 | BDKRB1 (0.42) | ALDH1A1KMT2AHSD11B1 | |
| SCHEMBL8068365 | 0.79 | RAB9A (0.42) | — | |
| SCHEMBL8067674 | 0.79 | ALDH1A1 (0.46) | ALDH1A1MCOLN3 | |
| SCHEMBL8053630 | 0.79 | RAB9A (0.41) | ALDH1A1KMT2AATM | |
| SCHEMBL4537337 | 0.77 | ATM (0.46) | ALDH1A1KMT2AMCOLN3HSD11B1ATM | |
| SCHEMBL4531364 | 0.75 | HSD11B1 (0.44) | ALDH1A1KMT2AMCOLN3HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |