Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8062139 | 0.91 | RAB9A (0.43) | RAB9ATSHRTP53L3MBTL1PSEN1 | |
| SCHEMBL4540868 | 0.90 | BDKRB1 (0.49) | BDKRB1RAB9ANCOA1NCOA3TSHR | |
| SCHEMBL8058321 | 0.90 | HTR7 (0.46) | BDKRB1 | |
| SCHEMBL4541024 | 0.87 | RAB9A (0.48) | BDKRB1RAB9AL3MBTL1PAX8GAA | |
| SCHEMBL8049742 | 0.86 | EPHX2 (0.39) | BDKRB1MCOLN3ALDH1A1 | |
| SCHEMBL8070991 | 0.83 | HSD11B1 (0.53) | — | |
| SCHEMBL8060066 | 0.82 | PSEN1 (0.50) | BDKRB1TSHRTP53PAX8PSEN1 | |
| SCHEMBL4541294 | 0.80 | PSEN1 (0.56) | BDKRB1TSHRPAX8PSEN1PSEN2 | |
| SCHEMBL4537833 | 0.80 | RAB9A (0.48) | RAB9ATSHRL3MBTL1PSEN1PSEN2 | |
| SCHEMBL4537242 | 0.80 | NPC1 (0.53) | BDKRB1RAB9AALDH1A1FKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |