Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.57 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.57 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.57 |
| ▸ | CTSL | P07711 | 3/20 | 0.56 |
| ▸ | KYNU | Q16719 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | CTSS | P25774 | 2/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CTSK | P43235 | 3/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4740486 | 0.96 | SIRT2 (0.56) | SIRT2SIRT1SIRT3CTSLKYNU | |
| Hydrochloric Acid SCHEMBL4740911 | 0.95 | SIRT2 (0.55) | SIRT2SIRT1SIRT3CTSLKYNU | |
| SCHEMBL8386880 | 0.90 | SIRT2 (0.67) | SIRT2SIRT1SIRT3CTSLKYNU | |
| SCHEMBL8058734 | 0.88 | ATM (0.49) | CTSLKYNUALDH1A1ALOX15CA1 | |
| SCHEMBL8447232 | 0.87 | SIRT2 (0.59) | SIRT2SIRT1SIRT3CTSLKYNU | |
| SCHEMBL8447229 | 0.87 | SIRT2 (0.59) | SIRT2SIRT1SIRT3CTSLKYNU | |
| Hydrochloric Acid SCHEMBL6236103 | 0.86 | SIRT2 (0.58) | SIRT2SIRT1SIRT3CTSLKYNU | |
| SCHEMBL1840311 | 0.86 | SIRT2 (0.61) | SIRT2SIRT1SIRT3CTSLKYNU | |
| SCHEMBL1840309 | 0.86 | SIRT2 (0.61) | SIRT2SIRT1SIRT3CTSLKYNU | |
| Hydrochloric Acid SCHEMBL6236109 | 0.86 | SIRT2 (0.58) | SIRT2SIRT1SIRT3CTSLKYNU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100093811-A1 | HIV PROTEASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2010-04-15 | — | — | US | disclosed |
| US-20100093811-A1 | HIV PROTEASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2010-04-15 | — | — | US | disclosed |
| WO-2009042093-A1 | HIV PROTEASE INHIBITORS | MERCK & CO., INC. (US) | 2009-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093811-A1 | HIV PROTEASE INHIBITORS | PRSS1, FURIN, SERPINB1 | SIRT2 1673/4885SIRT1 474/4885SIRT3 720/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.