SCHEMBL8064336

SCHEMBL8064336

O=Cc1ccc2cnn(-c3c(Cl)cc(C(F)(F)F)cc3Cl)c2c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP11B2 P19099 3/20 0.40
ACHE P22303 1/20 0.40
GABRB3 P28472 12/20 0.38
GABRA2 P47869 9/20 0.38
GABRB2 P47870 9/20 0.38
GABRP O00591 5/20 0.38
GABRD O14764 5/20 0.38
GABRA1 P14867 5/20 0.38
GABRB1 P18505 5/20 0.38
GABRG2 P18507 5/20 0.38
GABRA5 P31644 5/20 0.38
GABRA3 P34903 5/20 0.38
GABRA4 P48169 5/20 0.38
GABRE P78334 5/20 0.38
GABRA6 Q16445 5/20 0.38
GABRG1 Q8N1C3 5/20 0.38
GABRG3 Q99928 5/20 0.38
GABRQ Q9UN88 5/20 0.38
CYP11B1 P15538 1/20 0.36
NR3C1 P04150 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9210384 0.81 CYP11B2 (0.45) CYP11B2ACHEGABRB3GABRA2GABRB2
SCHEMBL8062385 0.81 GABRA2 (0.44) CYP11B2ACHEGABRB3GABRA2GABRB2
SCHEMBL8059782 0.81 GABRB3 (0.46) CYP11B2GABRB3GABRA2GABRB2GABRP
SCHEMBL8058879 0.81 GABRP (0.40) CYP11B2GABRB3GABRA2GABRB2GABRP
SCHEMBL8058876 0.81 GABRP (0.40) CYP11B2GABRB3GABRA2GABRB2GABRP
SCHEMBL8062287 0.79 GABRB3 (0.51) CYP11B2GABRB3GABRA2GABRB2GABRP
SCHEMBL9206083 0.78 MAPT (0.40) CYP11B2ACHEGABRB3GABRA2GABRB2
SCHEMBL8047202 0.78 NPBWR1 (0.48) CYP11B2GABRB3GABRA2GABRB2GABRP
SCHEMBL8062391 0.78 CYP11B2 (0.40) CYP11B2ACHEGABRB3GABRA2GABRB2
Carbon Tetrachloride SCHEMBL27438815 0.76 GABRA2 (0.45) CYP11B2ACHEGABRB3GABRA2GABRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0630367-B1 NOVEL ARYLINDAZOLES AND THEIR USE AS HERBICIDES ZENECA LTD (GB) 2000-07-05 EP disclosed
US-5928998-A PRE- AND POSTEMERGENCE HERBICIDES ZENECA LIMITED (GB) 1999-07-27 US disclosed
US-5444038-A Arylindazoles and their use as herbicides ZENECA LIMITED (GB) 1995-08-22 US disclosed
EP-0630367-A1 NOVEL ARYLINDAZOLES AND THEIR USE AS HERBICIDES ZENECA LIMITED (GB) 1994-12-28 EP disclosed
CN-1079961-A New arylindazoles and they are as the purposes of weedicide SERIAL (GB) 1993-12-29 CN disclosed
WO-1993018008-A1 NOVEL ARYLINDAZOLES AND THEIR USE AS HERBICIDES ZENECA LIMITED (GB) 1993-09-16 WO disclosed