Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ESRRA | P11474 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.38 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8068951 | 0.90 | LPAR1 (0.46) | SLC6A2SLC6A4MRGPRX4THRATHRB | |
| SCHEMBL8068627 | 0.86 | LPAR1 (0.48) | NOTUMSLC6A2SLC6A4MRGPRX4THRA | |
| SCHEMBL8068454 | 0.86 | THRA (0.44) | NOTUMSLC6A2SLC6A4MRGPRX4THRA | |
| Hydrochloric Acid SCHEMBL8059587 | 0.85 | SIRT1 (0.42) | SLC6A2SLC6A4THRATHRBSIRT1 | |
| Hydrochloric Acid SCHEMBL8059590 | 0.84 | SLC9A1 (0.41) | SLC6A2SLC6A4THRATHRBCYP3A4 | |
| SCHEMBL8068841 | 0.82 | THRA (0.40) | SLC6A2SLC6A4THRATHRBCYP3A4 | |
| SCHEMBL12239037 | 0.80 | LOXL2 (0.55) | NOTUMSLC6A2SLC6A4MRGPRX4CYP3A4 | |
| SCHEMBL8075068 | 0.75 | NOTUM (0.54) | NOTUMMRGPRX4CYP3A4ESRRAALDH1A1 | |
| SCHEMBL8059726 | 0.75 | THRA (0.47) | SLC6A2SLC6A4MRGPRX4THRATHRB | |
| SCHEMBL27195845 | 0.75 | THRA (0.60) | NOTUMMRGPRX4THRATHRBSIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057322-A | USEFUL IN TREATMENT OF CARDIOVASCULAR DISEASES | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-05-02 | — | — | US | disclosed |