Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 10/20 | 0.46 |
| ▸ | LPAR5 | Q9H1C0 | 10/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8068670 | 0.90 | NOTUM (0.43) | LPAR1LPAR5THRATHRBMRGPRX4 | |
| Hydrochloric Acid SCHEMBL8059590 | 0.86 | SLC9A1 (0.41) | LPAR1LPAR5THRATHRBSLC6A2 | |
| SCHEMBL8059726 | 0.85 | THRA (0.47) | LPAR1LPAR5THRATHRBRXRA | |
| Hydrochloric Acid SCHEMBL8059587 | 0.85 | SIRT1 (0.42) | LPAR1LPAR5THRATHRBSLC6A2 | |
| SCHEMBL8444218 | 0.81 | PKM (0.44) | LPAR1LPAR5THRATHRBSLC6A4 | |
| Hydrochloric Acid SCHEMBL8073687 | 0.80 | PKM (0.43) | LPAR1LPAR5THRATHRB | |
| SCHEMBL8068627 | 0.75 | LPAR1 (0.48) | LPAR1LPAR5THRATHRBMRGPRX4 | |
| SCHEMBL8068454 | 0.75 | THRA (0.44) | THRATHRBMRGPRX4SLC6A2SLC6A4 | |
| SCHEMBL8059639 | 0.74 | TTR (0.62) | LPAR1LPAR5RXRARXRBRXRG | |
| SCHEMBL8074970 | 0.73 | SLC6A2 (0.45) | LPAR1LPAR5THRATHRBSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057322-A | USEFUL IN TREATMENT OF CARDIOVASCULAR DISEASES | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-05-02 | — | — | US | disclosed |
| EP-0723956-B1 | Basically substituted benzoylguanidines, process for their preparation, their use as medicaments or diagnostics as well as medicaments containing them | HOECHST AG (DE) | 1999-10-13 | — | — | EP | disclosed |
| EP-0723956-A1 | Basically substituted benzoylguanidines, process for their preparation, their use as medicaments or diagnostics as well as medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-07-31 | — | — | EP | disclosed |