Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.50 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.50 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.50 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.50 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.50 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.50 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.48 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.44 |
| ▸ | LOX | P28300 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 4/20 | 0.43 |
| ▸ | HTR1B | P28222 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5808164 | 0.83 | PSEN1 (0.56) | BDKRB1ALDH1A1MEN1KMT2APSEN1 | |
| SCHEMBL8060028 | 0.82 | HTR7 (0.61) | HTR6LOXNPSR1HTR7HTR1B | |
| SCHEMBL5809151 | 0.82 | PSEN1 (0.57) | BDKRB1ALDH1A1MEN1KMT2APSEN1 | |
| SCHEMBL8069484 | 0.82 | PSEN1 (0.62) | ALDH1A1MEN1KMT2APSEN1PSEN2 | |
| SCHEMBL4543050 | 0.80 | BDKRB1 (0.52) | BDKRB1ALDH1A1MEN1KMT2APSEN1 | |
| SCHEMBL8060049 | 0.79 | ALDH1A1 (0.47) | ALDH1A1KMT2APSEN1PSEN2APH1B | |
| SCHEMBL5805423 | 0.78 | HTR7 (0.53) | ALDH1A1MEN1KMT2APSEN1PSEN2 | |
| SCHEMBL4538143 | 0.77 | RAB9A (0.50) | BDKRB1ALDH1A1MEN1KMT2APSEN1 | |
| SCHEMBL4536998 | 0.76 | BDKRB1 (0.49) | BDKRB1ALDH1A1MEN1KMT2AHCRTR1 | |
| Hydrochloric Acid SCHEMBL4616077 | 0.76 | FFAR1 (0.53) | MEN1KMT2AHTR6HTR7DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |