Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Methohexital. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 3/20 | 0.33 |
| ▸ | GABRG2 known ✓ | P18507 | 3/20 | 0.33 |
| ▸ | GABRB3 known ✓ | P28472 | 3/20 | 0.33 |
| ▸ | GABRB2 known ✓ | P47870 | 2/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methohexital SCHEMBL80730 | 1.00 | MMP9 (0.42) | MMP9NR1I2CYP3A4GABRA1GABRG2 | |
| Methohexital SCHEMBL20980055 | 1.00 | MMP9 (0.42) | MMP9NR1I2CYP3A4GABRA1GABRG2 | |
| Methohexital SCHEMBL19420179 | 1.00 | MMP9 (0.42) | MMP9NR1I2CYP3A4GABRA1GABRG2 | |
| Methohexital SCHEMBL11111822 | 1.00 | MMP9 (0.42) | MMP9NR1I2CYP3A4GABRA1GABRG2 | |
| Methohexital SCHEMBL5115660 | 0.99 | MMP9 (0.41) | MMP9NR1I2CYP3A4GABRA1GABRG2 | |
| SCHEMBL10581308 | 0.89 | MMP9 (0.39) | MMP9NR1I2CYP3A4LMNA | |
| Methohexital SCHEMBL13724704 | 0.86 | GABRA1 (0.33) | MMP9GABRA1GABRG2GABRB3GABRB2 | |
| Methohexital SCHEMBL4837768 | 0.86 | MMP9 (0.33) | MMP9GABRA1GABRG2GABRB3GABRB2 | |
| Methohexital SCHEMBL1003787 | 0.86 | LMNA (0.59) | MMP9GABRA1GABRG2GABRB3GABRB2 | |
| SCHEMBL17471557 | 0.85 | MMP9 (0.35) | MMP9NR1I2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 8682 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4719552-A1 | INDUCTION OF GENERAL ANESTHESIA IN ADULTS UNDERGOING ELECTIVE SURGERY | Xizang Haisco Pharmaceutical Co., Ltd. (CN) | 2026-04-08 | — | — | EP | claimed |
| US-12594388-B2 | Device to deliver a predetermined amount of a substance to a natural orifice of the body | APTARGROUP, INC. (US) | 2026-04-07 | — | — | US | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| WO-2025245279-A1 | NON-NATURALLY OCCURRING MELANOCORTIN RECEPTOR AGONISTS AND USE THEREFORE IN TREATMENT OF ADDICTION AND/OR PAIN | ENDEVICA BIO, INC. (US) | 2025-11-27 | — | — | WO | claimed |
| WO-2025245292-A1 | NON-NATURALLY OCCURRING MELANOCORTIN RECEPTOR AGONISTS AND USES THEREOF FOR MODULATING WEIGHT LOSS | ENDEVICA BIO, INC. (US) | 2025-11-27 | — | — | WO | claimed |
| WO-2025245294-A1 | NON-NATURALLY OCCURRING MELANOCORTIN RECEPTOR AGONISTS AND USES THEREOF FOR MODULATING WEIGHT GAIN | ENDEVICA BIO, INC. (US) | 2025-11-27 | — | — | WO | claimed |
| US-20250242092-A1 | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS | SIO2 MEDICAL PRODUCTS INC (US) | 2025-07-31 | — | — | US | claimed |
| US-20250235641-A1 | DEVICE TO DELIVER A PREDETERMINED AMOUNT OF A SUBSTANCE TO A NATURAL ORIFICE OF THE BODY | APTARGROUP INC. (US) | 2025-07-24 | — | — | US | claimed |
| WO-2025123059-A1 | NON-NATURALLY OCCURRING MELANOCORTIN ANALOGS AND USES THEREOF FOR TREATING SUBSTANCE USE DISORDERS | ENDEVICA BIO, INC. (US) | 2025-06-12 | — | — | WO | claimed |
| US-12257371-B2 | SiOx barrier for pharmaceutical package and coating process | SIO2 MEDICAL PRODUCTS, LLC (US) | 2025-03-25 | — | — | US | claimed |
| EP-0490916-A4 | COMPOSITIONS AND METHODS OF MANUFACTURE OF ORAL DISSOLVABLE MEDICAMENTS | — | 1992-08-12 | — | — | EP | claimed |
| EP-0487520-A4 | COMPRESSED POWDER MEDICAMENTS | — | 1992-08-12 | — | — | EP | claimed |
| EP-0490916-A1 | COMPOSITIONS AND METHODS OF MANUFACTURE OF ORAL DISSOLVABLE MEDICAMENTS. | UNIV UTAH RES FOUND (US) | 1992-06-24 | — | — | EP | claimed |
| EP-0487520-A1 | COMPRESSED POWDER MEDICAMENTS. | ANESTA CORP (US) | 1992-06-03 | — | — | EP | claimed |
| WO-1991003237-A1 | COMPOSITIONS AND METHODS OF MANUFACTURE OF ORAL DISSOLVABLE MEDICAMENTS | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 1991-03-21 | — | — | WO | claimed |
| EP-0200490-B1 | COMPOSITIONS FOR NONINVASIVE ADMINISTRATION OF SEDATIVES, ANALGESICS, AND ANESTHETICS | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 1991-03-20 | — | — | EP | claimed |
| WO-1991003099-A1 | COMPRESSED POWDER MEDICAMENTS | ANESTA CORPORATION (US) | 1991-03-07 | — | — | WO | claimed |
| US-4863737-A | TRANSMUCOSAL DELIVERY | UNIVERSITY OF UTAH (US) | 1989-09-05 | — | — | US | claimed |
| US-4557934-A | ALONG WITH A DIOL PYRROLIDONE OR AN AZACYCLOPENTAN-2-ONE | THE PROCTER & GAMBLE COMPANY (US) | 1985-12-10 | — | — | US | claimed |
| US-4126684-A | 4-AMINO-3-P-HALOPHENYLBUTYRIC ACIDS AND THEIR DERIVATIVES USED IN THE CONTROL OF NARCOTIC ABUSE | CIBA-GEIGY CORPORATION (US) | 1978-11-21 | — | — | US | claimed |