SCHEMBL8072983

SCHEMBL8072983

CC(C)(C)[Si](C)(C)OC(CCI)Cc1ccccc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 4/20 0.33
SIGMAR1 Q99720 3/20 0.33
SLC6A2 P23975 2/20 0.33
MAOA P21397 1/20 0.33
SLC6A4 P31645 1/20 0.33
SLC6A3 Q01959 1/20 0.33
CYP2A6 P11509 1/20 0.33
ADORA2A P29274 1/20 0.33
ADORA1 P30542 1/20 0.33
ALDH1A1 P00352 1/20 0.33
HPGD P15428 1/20 0.33
ALOX15 P16050 1/20 0.33
ALOX12 P18054 1/20 0.33
CASP1 P29466 1/20 0.33
HSD17B10 Q99714 1/20 0.33
SLC18A2 Q05940 1/20 0.32
CYP2D6 P10635 1/20 0.32
EPHX1 P07099 1/20 0.32
TRPA1 O75762 1/20 0.31
CTSK P43235 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10086857 0.87 ALDH1A1 (0.40) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL17375167 0.85 ALDH1A1 (0.41) TAAR1SIGMAR1SLC6A2MAOASLC6A4
SCHEMBL20436626 0.85 TRPA1 (0.38) TAAR1SIGMAR1SLC6A2MAOASLC6A4
SCHEMBL24111209 0.78 CYP1A2 (0.37) CTSKCTSLCTSB
SCHEMBL24111210 0.78 LTA4H (0.46)
SCHEMBL13594158 0.77 SIGMAR1 (0.44) TAAR1SIGMAR1SLC6A2MAOASLC6A4
SCHEMBL21280529 0.75 CA2 (0.37) SIGMAR1SLC6A2SLC6A4SLC6A3ALOX15
SCHEMBL15880757 0.74 POLB (0.35) TAAR1SIGMAR1SLC6A2MAOASLC6A4
SCHEMBL9621418 0.74 TRPA1 (0.40) TAAR1SIGMAR1SLC6A2MAOASLC6A4
SCHEMBL388942 0.74 EPHX1 (0.48) TAAR1SIGMAR1SLC6A2MAOASLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018140738-A1 NRF 2 ACTIVATOR BIOGEN MA INC. (US) 2018-08-02 WO disclosed
EP-0778269-B1 PROSTAGLANDINS AND PROCESS FOR PRODUCING THE SAME TEIJIN LTD (JP) 2000-09-27 EP disclosed
US-5990346-A AN INHIBITORS OF CELL MIGRATION CAUSED BY CHEMOKINES TEIJIN LIMITED (JP) 1999-11-23 US disclosed
EP-0778269-A1 PROSTAGLANDINS AND PROCESS FOR PRODUCING THE SAME TEIJIN LIMITED (JP) 1997-06-11 EP disclosed