Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8062696 | 0.94 | IDO1 (0.42) | L3MBTL1MAOASIGMAR1IDO1 | |
| SCHEMBL8071578 | 0.86 | MMP12 (0.42) | — | |
| SCHEMBL8063607 | 0.81 | L3MBTL1 (0.47) | L3MBTL1MAOASIGMAR1MAOBIDO1 | |
| SCHEMBL28912103 | 0.78 | KDM4E (0.40) | L3MBTL1SIGMAR1 | |
| SCHEMBL6681949 | 0.78 | MAOA (0.52) | L3MBTL1MAOASIGMAR1MAOB | |
| SCHEMBL18931634 | 0.77 | TDP1 (0.48) | L3MBTL1 | |
| SCHEMBL6682661 | 0.76 | SIGMAR1 (0.52) | MAOASIGMAR1MAOB | |
| SCHEMBL6684932 | 0.76 | SIGMAR1 (0.52) | MAOASIGMAR1MAOB | |
| SCHEMBL6682926 | 0.76 | SIGMAR1 (0.52) | MAOASIGMAR1MAOB | |
| SCHEMBL15929720 | 0.75 | TRPA1 (0.45) | L3MBTL1MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127426-A | ANTIALLERGIC AND -INFLAMMATORY AGENTS E.G., TREATING PSORIASIS, BLOCKED ON THE C-10 BY A NONPHENOLIC ARYLACYL OR A PHENYLALKYLIDENE GROUP; LIPOXYGENASE INHIBITORS; ANTIPROLIFERATIVE AGENTS; LOW DOSAGE; SIDE EFFECT REDUCTION | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2000-10-03 | — | — | US | disclosed |
| EP-0664780-B1 | 10-SUBSTITUTED 1,8-DIHYDROXY-9(10H) ANTHRACENONE PHARMACEUTICALS | TEVA PHARMA (IL) | 1999-12-08 | — | — | EP | disclosed |
| US-5952390-A | ANTIINFLAMMATORY AGENTS; TREATMENT FOR PSORIASIS | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 1999-09-14 | — | — | US | disclosed |
| US-5844004-A | 10-substituted 1,8-dihydroxy-9 (10H) anthracenone pharmaceuticals | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1998-12-01 | — | — | US | disclosed |
| US-5661187-A | ADMINISTERING TO TREAT AN ALLERGIC OR INFLAMMATORY CONDITION; SIDE EFFECT REDUCTION | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1997-08-26 | — | — | US | disclosed |
| EP-0664780-A1 | 10-SUBSTITUTED 1,8-DIHYDROXY-9(10H) ANTHRACENONE PHARMACEUTICALS | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 1995-08-02 | — | — | EP | disclosed |
| US-5426197-A | Antiinflammatory, antiallergy or antitumor agents | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1995-06-20 | — | — | US | disclosed |
| WO-1995003266-A1 | 10-SUBSTITUTED 1,8-DIHYDROXY-9(10H) ANTHRACENONE PHARMACEUTICALS | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1995-02-02 | — | — | WO | disclosed |