SCHEMBL8073574

SCHEMBL8073574

C[C](C(C)=O)C12CC3CC(CC(C3)C1)C2

nearest known ligand 0.52

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
EPHX1 P07099 3/20 0.44
HSD11B1 P28845 5/20 0.44
GLA P06280 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.43
CA2 P00918 1/20 0.41
ALDH1A1 P00352 3/20 0.40
MAPT P10636 1/20 0.40
POLB P06746 1/20 0.40
CRHBP P24387 1/20 0.39
HTT P42858 1/20 0.39
CRHR2 Q13324 1/20 0.39
MCOLN3 Q8TDD5 1/20 0.39
EPHX2 P34913 1/20 0.39
TSHR P16473 1/20 0.39
LMNA P02545 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17818754 0.81 ALDH1A1 (0.46) EPHX1HSD11B1GLAL3MBTL1CA2
SCHEMBL19757635 0.79 HSD11B1 (0.47) EPHX1HSD11B1GLAL3MBTL1CA2
SCHEMBL159994 0.79 HSD11B1 (0.47) EPHX1HSD11B1GLAL3MBTL1CA2
Acetic Acid SCHEMBL27574386 0.75 HSD11B1 (0.44) EPHX1HSD11B1GLAL3MBTL1CA2
Acetic Acid SCHEMBL2777409 0.75 ALDH1A1 (0.49) EPHX1HSD11B1GLAL3MBTL1CA2
SCHEMBL8533984 0.75 ALDH1A1 (0.50) HSD11B1GLAL3MBTL1ALDH1A1HTT
SCHEMBL251840 0.73 HSD11B1 (0.50) EPHX1HSD11B1GLAL3MBTL1ALDH1A1
SCHEMBL40512 0.73 ALDH1A1 (0.42) EPHX1HSD11B1GLAL3MBTL1CA2
SCHEMBL677939 0.73 ALDH1A1 (0.42) EPHX1HSD11B1GLAL3MBTL1CA2
SCHEMBL3322717 0.71 SCN1A (0.47) HSD11B1GLAL3MBTL1CA2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0641208-B1 4-AZASTEROID 5-ALPHA-REDUCTASE INHIBITORS MERCK & CO INC (US) 2000-08-02 EP claimed
EP-0778284-A2 New 7-beta-substituted-4-aza-5alpha-androstan-3-ones as 5alpha-reductase inhibitors MERCK & CO. INC. (US) 1997-06-11 EP claimed
EP-0641208-A4 4-AZASTEROID 5-ALPHA-REDUCTASE INHIBITORS. MERCK & CO INC (US) 1995-08-30 EP claimed
EP-0641208-A1 4-AZASTEROID 5-ALPHA-REDUCTASE INHIBITORS MERCK & CO. INC. (US) 1995-03-08 EP claimed
WO-1993023420-A1 NEW 7β-SUBSTITUTED-4-AZA-5α-ANDROSTAN-3-ONES AS 5α-REDUCTASE INHIBITORS MERCK & CO., INC. (US) 1993-11-25 WO claimed
WO-1993023039-A1 SUBSTITUTED 4-AZA-5A-ANDROSTAN-ONES AS 5A-REDUCTASE INHIBITORS MERCK & CO., INC. (US) 1993-11-25 WO claimed
WO-1993023048-A1 4-AZASTEROID 5-ALPHA-REDUCTASE INHIBITORS MERCK & CO., INC. (US) 1993-11-25 WO claimed
EP-0641208-B1 4-AZASTEROID 5-ALPHA-REDUCTASE INHIBITORS MERCK & CO INC (US) 2000-08-02 EP disclosed
WO-1993023048-A1 4-AZASTEROID 5-ALPHA-REDUCTASE INHIBITORS MERCK & CO., INC. (US) 1993-11-25 WO disclosed