Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | PRKCI | P41743 | 7/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | HTR6 | P50406 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2395616 | 0.87 | ITK (0.56) | ITKLCKAURKBSSTR5RORC | |
| SCHEMBL10286645 | 0.82 | ITK (0.44) | ITKLCKAURKBSSTR5RORC | |
| SCHEMBL807946 | 0.81 | ITK (0.58) | ITKLCKAURKBSSTR5RORC | |
| SCHEMBL807743 | 0.80 | ITK (0.57) | ITKLCKAURKBSSTR5RORC | |
| SCHEMBL808093 | 0.80 | ITK (0.61) | ITKLCKAURKBSSTR5RORC | |
| SCHEMBL807803 | 0.80 | ITK (0.58) | ITKLCKAURKBSSTR5RORC | |
| SCHEMBL808096 | 0.79 | ITK (0.51) | ITKLCKAURKBSSTR5RORC | |
| SCHEMBL10285825 | 0.78 | ITK (0.58) | ITKLCKAURKBSSTR5RORC | |
| SCHEMBL808081 | 0.77 | ITK (0.54) | ITKLCKAURKBSSTR5RORC | |
| SCHEMBL10285603 | 0.75 | ITK (0.45) | ITKLCKAURKBSSTR5RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012035055-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-22 | — | — | WO | disclosed |