Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 2/20 | 0.54 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | HCK | P08631 | 7/20 | 0.38 |
| ▸ | BTK | Q06187 | 7/20 | 0.38 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 2/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | MLNR | O43193 | 2/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.32 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL807946 | 0.90 | ITK (0.58) | ITKRORCDHODHHCKBTK | |
| SCHEMBL807743 | 0.87 | ITK (0.57) | ITKRORCDHODHHCKBTK | |
| SCHEMBL808093 | 0.84 | ITK (0.61) | ITKRORCDHODHHCKBTK | |
| SCHEMBL807803 | 0.83 | ITK (0.58) | ITKRORCDHODHHCKBTK | |
| SCHEMBL10285825 | 0.82 | ITK (0.58) | ITKRORCDHODHHCKBTK | |
| SCHEMBL807926 | 0.81 | ITK (0.59) | ITKRORCDHODHHCKBTK | |
| SCHEMBL2395616 | 0.80 | ITK (0.56) | ITKRORCDHODHBTKSSTR5 | |
| SCHEMBL808096 | 0.80 | ITK (0.51) | ITKRORCDHODHHCKBTK | |
| SCHEMBL807541 | 0.79 | ITK (0.55) | ITKRORCDHODHSSTR5LCK | |
| SCHEMBL807540 | 0.77 | ITK (0.46) | ITKRORCDHODHSSTR5LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012035055-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-22 | — | — | WO | disclosed |