Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.52 |
| ▸ | PDE5A | O76074 | 3/20 | 0.43 |
| ▸ | PDE4A | P27815 | 3/20 | 0.43 |
| ▸ | PDE1A | P54750 | 3/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8085083 | 0.85 | ALOX5 (0.55) | ALOX5PDE5APDE4APDE1APDE1B | |
| SCHEMBL6913485 | 0.84 | ALOX5 (0.72) | ALOX5PDE5APDE4APDE1APDE1B | |
| SCHEMBL7657876 | 0.84 | ALDH1A1 (0.40) | ALDH1A1MAPTHPGDKDM4ENPC1 | |
| SCHEMBL8086618 | 0.82 | ALOX5 (0.52) | ALOX5PDE5APDE4APDE1APDE1B | |
| SCHEMBL8081890 | 0.78 | ALOX5 (0.62) | ALOX5ALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL8081514 | 0.76 | TARBP2 (0.43) | PDE1APDE1BPDE1CALDH1A1MAPT | |
| SCHEMBL8072530 | 0.76 | GPR35 (0.46) | ALDH1A1MAPTHPGDSMN1; SMN2KDM4E | |
| SCHEMBL8080517 | 0.76 | APP (0.41) | ALOX5ALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL8080755 | 0.75 | TARBP2 (0.42) | PDE1APDE1BPDE1CALDH1A1MAPT | |
| SCHEMBL8072485 | 0.75 | ALOX5 (0.44) | ALOX5ALDH1A1MAPTHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |