Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8085083 | 0.89 | ALOX5 (0.55) | ALOX5PTGS2ADORA1ADORA2ATSHR | |
| SCHEMBL8072500 | 0.85 | XDH (0.37) | PTGS2ADORA1ADORA2ATSHRALDH1A1 | |
| SCHEMBL8081276 | 0.78 | ALDH1A1 (0.33) | PTGS2ADORA1ADORA2ATSHRALDH1A1 | |
| SCHEMBL6913485 | 0.77 | ALOX5 (0.72) | ALOX5ADORA1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8086618 | 0.77 | ALOX5 (0.52) | ALOX5PTGS2ALDH1A1KMT2AMEN1 | |
| SCHEMBL8081890 | 0.75 | ALOX5 (0.62) | ALOX5ADORA1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8080370 | 0.75 | ALOX5 (0.52) | ALOX5TSHRALDH1A1HPGDKMT2A | |
| SCHEMBL7655215 | 0.74 | PTGS2 (0.41) | ALOX5PTGS2HSP90AA1HSP90AB1KMT2A | |
| SCHEMBL8072723 | 0.74 | ALOX5 (0.36) | ALOX5PTGS2ALDH1A1HPGDKMT2A | |
| SCHEMBL8081282 | 0.73 | ALDH1A1 (0.32) | PTGS2TSHRALDH1A1HPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |