Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.34 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.34 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 3/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8086814 | 0.81 | ALOX5 (0.55) | ALOX5KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL8072723 | 0.76 | ALOX5 (0.36) | ALOX5KDM4EALDH1A1GAAMAPT | |
| SCHEMBL8081547 | 0.76 | ALOX5 (0.38) | ALOX5KDM4EALDH1A1GAAMAPT | |
| SCHEMBL8085193 | 0.75 | ALOX5 (0.48) | ALOX5KDM4EALDH1A1GAAMAPT | |
| SCHEMBL8072765 | 0.70 | PTGS2 (0.45) | ALOX5ALDH1A1HPGDMEN1TSHR | |
| SCHEMBL8081276 | 0.68 | ALDH1A1 (0.33) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL8081905 | 0.66 | ALOX5 (0.45) | ALOX5KDM4EALDH1A1HPGDEDNRA | |
| SCHEMBL8085222 | 0.65 | KDM4E (0.40) | ALOX5KDM4EALDH1A1GAAMAPT | |
| SCHEMBL6913485 | 0.65 | ALOX5 (0.72) | ALOX5KDM4EALDH1A1MAPTCYP3A4 | |
| SCHEMBL8085133 | 0.64 | KDM4E (0.41) | ALOX5KDM4EALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |