Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8072723 | 0.86 | ALOX5 (0.36) | ALDH1A1HPGDKDM4EMEN1MAPT | |
| SCHEMBL8072485 | 0.78 | ALOX5 (0.44) | ALDH1A1HPGDALOX15TSHRMAPK1 | |
| SCHEMBL8081282 | 0.77 | ALDH1A1 (0.32) | ALDH1A1HPGDALOX15TSHRMAPK1 | |
| SCHEMBL8072500 | 0.74 | XDH (0.37) | ALDH1A1HPGDALOX15TSHRMAPK1 | |
| SCHEMBL8081541 | 0.68 | ALOX5 (0.40) | ALDH1A1HPGDTSHRMAPK1HSD17B10 | |
| SCHEMBL8085083 | 0.67 | ALOX5 (0.55) | ALDH1A1HPGDALOX15TSHRMAPK1 | |
| SCHEMBL8072729 | 0.66 | PTGS2 (0.34) | ALDH1A1HPGDKDM4EMEN1MAPT | |
| SCHEMBL8081497 | 0.66 | TARBP2 (0.39) | ALDH1A1HPGDTSHRMAPK1HSD17B10 | |
| SCHEMBL8081514 | 0.64 | TARBP2 (0.43) | ALDH1A1HPGDTSHRMAPK1HSD17B10 | |
| SCHEMBL8085093 | 0.63 | KDM4E (0.43) | ALDH1A1HPGDTSHRMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |