Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.46 |
| ▸ | CTSD | P07339 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8833707 | 0.86 | TSHR (0.60) | TSHRALDH1A1GPR35CTSDTDP1 | |
| SCHEMBL5780887 | 0.81 | TDP1 (0.56) | TSHRALDH1A1GPR35TDP1PLAU | |
| SCHEMBL8834277 | 0.81 | ALDH1A1 (0.52) | TSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL436389 | 0.77 | ALDH1A1 (0.66) | TSHRALDH1A1GPR35CTSDTDP1 | |
| SCHEMBL7437947 | 0.77 | GPR35 (0.58) | TSHRALDH1A1GPR35CTSDTDP1 | |
| SCHEMBL3345170 | 0.74 | TDP1 (0.48) | TSHRALDH1A1GPR35TDP1PLAU | |
| SCHEMBL28059536 | 0.73 | SMN1; SMN2 (0.47) | TSHRALDH1A1GPR35TDP1CYP3A4 | |
| SCHEMBL28175713 | 0.73 | TSHR (0.60) | TSHRALDH1A1GPR35TDP1PLAU | |
| SCHEMBL8082546 | 0.72 | TDP1 (0.47) | TSHRALDH1A1GPR35CTSDTDP1 | |
| SCHEMBL28423348 | 0.71 | TSHR (0.58) | TSHRALDH1A1GPR35CTSDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6159988-A | Arylcycloalkyl derivatives, their production and their use | HOESCHST AKTIENGESELLSCHAFT (DE) | 2000-12-12 | — | — | US | disclosed |
| US-5776977-A | Arylcycloalkyl derivatives, their production and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-07-07 | — | — | US | disclosed |
| US-5589514-A | ANTIINFLAMMATORY | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-12-31 | — | — | US | disclosed |
| EP-0551849-B1 | Novel arylcycloalkyl derivatives their production and their use | HOECHST AG (DE) | 1996-10-09 | — | — | EP | disclosed |
| EP-0551849-A1 | Novel arylcycloalkyl derivatives their production and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-07-21 | — | — | EP | disclosed |