Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | PTPN7 | P35236 | 3/20 | 0.45 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8099045 | 0.88 | MAPT (0.39) | ALDH1A1PTPN7KDM4EHPGDKMT2A | |
| SCHEMBL8084155 | 0.87 | MAPT (0.39) | ALDH1A1PTPN7KDM4EHPGDKMT2A | |
| SCHEMBL8084833 | 0.86 | CA12 (0.43) | ALDH1A1KMT2AMEN1POLBSMN1; SMN2 | |
| SCHEMBL8084016 | 0.86 | CA12 (0.41) | ALDH1A1KDM4EKMT2AMEN1POLB | |
| SCHEMBL8090948 | 0.86 | CA12 (0.41) | ALDH1A1KDM4EKMT2AMEN1POLB | |
| SCHEMBL8092498 | 0.85 | PIK3CD (0.49) | ALDH1A1DUSP3KDM4EHPGDKMT2A | |
| SCHEMBL8091191 | 0.84 | PIK3CA (0.40) | PIK3CDPIK3CAMTORPIK3CGCA1 | |
| SCHEMBL8091293 | 0.84 | MAPT (0.42) | ALDH1A1KDM4EHPGDKMT2AMEN1 | |
| SCHEMBL8092502 | 0.83 | PIK3CD (0.45) | ALDH1A1DUSP3KDM4EHPGDKMT2A | |
| SCHEMBL8092307 | 0.83 | PIK3CA (0.39) | ALDH1A1PTPN7DUSP3KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |