Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100A4 | P26447 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8090068 | 0.90 | ALDH1A1 (0.34) | KDM4EALDH1A1SMN1; SMN2POLBHPGD | |
| SCHEMBL8088362 | 0.87 | SLC9A1 (0.30) | — | |
| SCHEMBL8085332 | 0.86 | ALDH1A1 (0.46) | ALDH1A1MAPTRECQL | |
| SCHEMBL8084221 | 0.82 | — | — | |
| SCHEMBL8090648 | 0.81 | ABCC9 (0.35) | KDM4E | |
| SCHEMBL8085297 | 0.81 | MAPT (0.35) | S100A4ALDH1A1POLBMAPT | |
| SCHEMBL8077225 | 0.78 | HSD17B1 (0.35) | S100A4KDM4EALDH1A1SMN1; SMN2HSD17B1 | |
| SCHEMBL8088434 | 0.76 | S100A4 (0.37) | S100A4KDM4EALDH1A1SMN1; SMN2POLB | |
| SCHEMBL9372349 | 0.69 | RAB9A (0.37) | ALDH1A1SMN1; SMN2POLBMAPT | |
| SCHEMBL10697118 | 0.69 | RAB9A (0.37) | ALDH1A1SMN1; SMN2POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| US-5013853-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1991-05-07 | — | — | US | disclosed |
| EP-0340718-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1989-11-08 | — | — | EP | disclosed |