Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1091565 | 0.71 | GPR84 (0.35) | LMNA | |
| SCHEMBL9754870 | 0.71 | ALDH1A1 (0.39) | MAPTALDH1A1HPGD | |
| SCHEMBL8087155 | 0.69 | AKR1B1 (0.42) | LMNAALDH1A1 | |
| SCHEMBL595273 | 0.68 | ALDH1A1 (0.35) | MAPTKMT2AALDH1A1ATM | |
| SCHEMBL29261888 | 0.68 | HTR6 (0.43) | — | |
| SCHEMBL11739195 | 0.64 | GPR84 (0.36) | MEN1MAPTKMT2ALMNAALDH1A1 | |
| SCHEMBL1132530 | 0.64 | SLC7A5 (0.50) | MEN1MAPTKMT2ALMNA | |
| SCHEMBL2159745 | 0.63 | IDO1 (0.33) | MAPTLMNAALDH1A1HPGD | |
| SCHEMBL3096746 | 0.63 | APAF1 (0.33) | MEN1MAPTKMT2ALMNAALDH1A1 | |
| SCHEMBL323144 | 0.63 | CYP1A2 (0.33) | MEN1MAPTKMT2ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080743-A | AS CHEMICAL INTERMEIDATES FOR PREPARING DRUGS | NOVARTIS AG (CH) | 2000-06-27 | — | — | US | disclosed |
| EP-0853617-A1 | NOVEL 2,3-DIOXO-1,2,3,4-TETRAHYDRO-QUINOYXALINYL DERIVATIVES | Novartis AG (CH) | 1998-07-22 | — | — | EP | disclosed |
| WO-1997008155-A1 | NOVEL 2,3-DIOXO-1,2,3,4-TETRAHYDRO-QUINOYXALINYL DERIVATIVES | NOVARTIS AG (CH) | 1997-03-06 | — | — | WO | disclosed |