Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | EDNRB | P24530 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.40 |
| ▸ | PREP | P48147 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8081344 | 0.90 | PTGS2 (0.42) | EDNRAKDM4EALDH1A1HPGDEDNRB | |
| SCHEMBL8081515 | 0.90 | EDNRA (0.45) | EDNRAKDM4EALDH1A1HPGDEDNRB | |
| SCHEMBL8084976 | 0.89 | EDNRB (0.50) | EDNRAKDM4EALDH1A1HPGDEDNRB | |
| SCHEMBL8081346 | 0.88 | NPC1 (0.48) | EDNRAKDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL8072530 | 0.79 | GPR35 (0.46) | EDNRAKDM4EALDH1A1HPGDEDNRB | |
| SCHEMBL8086669 | 0.79 | CYP19A1 (0.40) | EDNRAALDH1A1HPGDEDNRBNPC1 | |
| SCHEMBL8080564 | 0.78 | CDK2 (0.41) | EDNRAKDM4EALDH1A1HPGDEDNRB | |
| SCHEMBL8472452 | 0.76 | SMN1; SMN2 (0.48) | EDNRAKDM4EALDH1A1HPGDEDNRB | |
| SCHEMBL8072741 | 0.75 | ALOX5 (0.38) | EDNRAALDH1A1HPGDNPC1TARBP2 | |
| SCHEMBL8081363 | 0.75 | PTGS2 (0.44) | EDNRAKDM4EALDH1A1HPGDEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |