Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | CDC42 | P60953 | 1/20 | 0.34 |
| ▸ | RAC1 | P63000 | 1/20 | 0.34 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL459934 | 0.84 | CA12 (0.44) | RAB9ASMN1; SMN2MAPTTP53CYP1A2 | |
| SCHEMBL6841236 | 0.83 | MEN1 (0.38) | RAB9AMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL5622659 | 0.81 | ACHE (0.45) | RAB9AMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL6494848 | 0.80 | LMNA (0.36) | RAB9AMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL8529054 | 0.80 | AHR (0.42) | — | |
| SCHEMBL11205461 | 0.79 | APP (0.39) | RAB9ASMN1; SMN2TP53NPC1 | |
| SCHEMBL8095649 | 0.79 | MAPT (0.34) | RAB9ASMN1; SMN2MAPTTP53GAA | |
| SCHEMBL4468568 | 0.79 | MEN1 (0.40) | RAB9AMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL10918406 | 0.79 | CYP11B1 (0.44) | RAB9AMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL3262111 | 0.79 | ESR2 (0.52) | RAB9AMEN1KMT2ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051394-A1 | POTASSIUM CHANNEL INHIBITORS | Icagen, Inc. (US) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999037607-A1 | POTASSIUM CHANNEL INHIBITORS | ICAGEN, INC. (US) | 1999-07-29 | — | — | WO | disclosed |