Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.32 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.30 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8090876 | 1.00 | MCHR1 (0.33) | MCHR1ADRA2ASLC6A2SLC6A4 | |
| Fumaric Acid SCHEMBL8093372 | 0.92 | ADRA2A (0.36) | ADRA2ASLC6A2SLC6A4 | |
| Fumaric Acid SCHEMBL8093365 | 0.92 | ADRA2A (0.36) | ADRA2ASLC6A2SLC6A4 | |
| SCHEMBL6960180 | 0.90 | ADRA2A (0.37) | MCHR1ADRA2A | |
| Fumaric Acid SCHEMBL8092403 | 0.85 | ADRA2A (0.46) | ADRA2A | |
| Fumaric Acid SCHEMBL8092398 | 0.85 | ADRA2A (0.46) | ADRA2A | |
| Fumaric Acid SCHEMBL8091878 | 0.85 | ADRA2A (0.46) | ADRA2A | |
| Fumaric Acid SCHEMBL8091870 | 0.85 | ADRA2A (0.46) | ADRA2A | |
| Fumaric Acid SCHEMBL8085007 | 0.85 | ADRA2A (0.46) | ADRA2A | |
| Fumaric Acid SCHEMBL8085005 | 0.85 | ADRA2A (0.46) | ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127396-A | Imidazoline compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |