Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.43 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.43 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.43 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8091780 | 0.89 | SIGMAR1 (0.53) | SIGMAR1MEN1KMT2APOLBL3MBTL1 | |
| SCHEMBL8093024 | 0.84 | SIGMAR1 (0.51) | SIGMAR1MEN1KMT2APOLBL3MBTL1 | |
| SCHEMBL9752778 | 0.84 | MEN1 (0.46) | SIGMAR1MEN1KMT2APOLBL3MBTL1 | |
| SCHEMBL8099093 | 0.84 | SIGMAR1 (0.52) | SIGMAR1MEN1KMT2APOLBL3MBTL1 | |
| SCHEMBL9378564 | 0.84 | SIGMAR1 (0.51) | SIGMAR1MEN1KMT2APOLBPLAAT3 | |
| SCHEMBL8084187 | 0.84 | SIGMAR1 (0.52) | SIGMAR1MEN1KMT2APOLBL3MBTL1 | |
| SCHEMBL8092957 | 0.83 | L3MBTL1 (0.56) | SIGMAR1MEN1KMT2APOLBL3MBTL1 | |
| SCHEMBL9372954 | 0.82 | SIGMAR1 (0.53) | SIGMAR1MEN1KMT2APOLBPLAAT3 | |
| SCHEMBL9752836 | 0.82 | DRD2 (0.45) | SIGMAR1MEN1KMT2APOLBPLAAT3 | |
| SCHEMBL8092622 | 0.80 | SIGMAR1 (0.55) | SIGMAR1MEN1KMT2APOLBCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057371-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-02 | — | — | US | claimed |
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | claimed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | claimed |
| WO-1991009594-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1991-07-11 | — | — | WO | claimed |