Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | MTOR | P42345 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8099967 | 0.92 | RAB9A (0.41) | KMT2AMEN1MTORRAB9APOLB | |
| SCHEMBL8090195 | 0.86 | RAB9A (0.47) | KMT2AMEN1MTORRAB9APOLB | |
| SCHEMBL8083976 | 0.85 | NPC1 (0.52) | KMT2AMEN1MTORRAB9APOLB | |
| SCHEMBL8093540 | 0.84 | RAB9A (0.39) | KMT2AMEN1MTORRAB9APOLB | |
| SCHEMBL8084988 | 0.82 | RAB9A (0.41) | KMT2AMEN1MTORRAB9APOLB | |
| SCHEMBL8098775 | 0.82 | CA1 (0.43) | KMT2AMEN1MTORMAPTPIK3CA | |
| SCHEMBL4003207 | 0.82 | PIK3CA (0.52) | MTORPIK3CAPIK3CG | |
| SCHEMBL8090158 | 0.81 | MTOR (0.46) | MTORPIK3CAPIK3CGCA2CA9 | |
| SCHEMBL8098814 | 0.81 | EPHX1 (0.47) | KMT2AMEN1RAB9APOLBMAPT | |
| SCHEMBL8096186 | 0.81 | MAPT (0.41) | MAPTPIK3CACA2CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |