Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 7/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8092270 | 0.90 | NPC1 (0.43) | RAB9AMTORKMT2AMEN1NPC1 | |
| SCHEMBL8099967 | 0.88 | RAB9A (0.41) | RAB9APOLBMTORKMT2AMEN1 | |
| SCHEMBL8096070 | 0.86 | MTOR (0.40) | MTORKMT2AATRPIK3CAPIK3R1 | |
| SCHEMBL8090195 | 0.85 | RAB9A (0.47) | RAB9APOLBMTORKMT2AMEN1 | |
| SCHEMBL8096681 | 0.84 | ATR (0.40) | MTORKMT2AMEN1ATRPIK3CA | |
| SCHEMBL8091838 | 0.84 | KMT2A (0.43) | RAB9APOLBMTORKMT2AMEN1 | |
| SCHEMBL8092294 | 0.83 | ROCK2 (0.39) | MTORNPC1ATRPIK3CAPIK3R1 | |
| SCHEMBL8098135 | 0.82 | MTOR (0.39) | MTORATRPIK3CAPIK3R1 | |
| SCHEMBL4006953 | 0.82 | PIK3CA (0.51) | MTORATRPIK3CA | |
| SCHEMBL8091129 | 0.82 | KDR (0.40) | RAB9AATRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |