Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8089595 | 0.85 | MAPT (0.46) | TSHRNPC1LMNAGAAALOX15 | |
| SCHEMBL8095087 | 0.83 | RNASEH1 (0.42) | RNASEH1KDM4AKDM5AKDM5BLMNA | |
| SCHEMBL8088554 | 0.80 | DYRK1A (0.40) | RNASEH1KDM4AKDM5AKDM5BDYRK1A | |
| SCHEMBL8525719 | 0.73 | PTK2 (0.65) | PTK2TSHRNPC1LMNAGAA | |
| SCHEMBL744649 | 0.71 | PTK2 (0.61) | PTK2TSHRNPC1LMNAGAA | |
| SCHEMBL7682574 | 0.68 | KDM4A (0.43) | RNASEH1KDM4AKDM5AKDM5BALDH1A1 | |
| SCHEMBL7680945 | 0.68 | PTPRC (0.44) | RNASEH1KDM4AKDM5AKDM5BLMNA | |
| SCHEMBL8081430 | 0.68 | PTK2 (0.41) | PTK2RNASEH1KDM4AKDM5AKDM5B | |
| SCHEMBL8095077 | 0.67 | MAPT (0.40) | TSHRNPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL7074236 | 0.67 | POLB (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054667-A1 | BICYCLIC PYRROLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANTIINFLAMMATORY AND IMMUNOMODULATING AGENTS | AstraZeneca UK Limited (GB) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999040913-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA UK LIMITED (GB) | 1999-08-19 | — | — | WO | disclosed |