Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | BUB1 | O43683 | 2/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.33 |
| ▸ | ALKBH3 | Q96Q83 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 3/20 | 0.32 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.32 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.32 |
| ▸ | BRD7 | Q9NPI1 | 2/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8093064 | 0.80 | PTK2 (0.47) | DYRK1AMAPTL3MBTL1BUB1CCR2 | |
| SCHEMBL8089595 | 0.73 | MAPT (0.46) | MEN1KMT2APOLBMAPTL3MBTL1 | |
| SCHEMBL8095087 | 0.64 | RNASEH1 (0.42) | MEN1KMT2APOLBMAPTL3MBTL1 | |
| SCHEMBL18796774 | 0.63 | PDE3B (0.71) | MEN1KMT2AL3MBTL1RNASEH1ALKBH3 | |
| SCHEMBL7049651 | 0.62 | RAB9A (0.48) | KMT2APOLBMAPTCCR2BRD4 | |
| SCHEMBL3298586 | 0.60 | IDO1 (0.64) | POLBALDH1A1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2301312 | 0.57 | LMNA (0.60) | DYRK1AMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL6921110 | 0.57 | DYRK1A (1.00) | DYRK1AMEN1KMT2APOLBMAPT | |
| SCHEMBL1691780 | 0.56 | SIGMAR1 (0.50) | KMT2APOLBALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL8303374 | 0.56 | KCNH2 (0.51) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054667-A1 | BICYCLIC PYRROLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANTIINFLAMMATORY AND IMMUNOMODULATING AGENTS | AstraZeneca UK Limited (GB) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999040913-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA UK LIMITED (GB) | 1999-08-19 | — | — | WO | disclosed |