Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNASEH1 | O60930 | 1/20 | 0.42 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | PTGFR | P43088 | 1/20 | 0.36 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8093064 | 0.83 | PTK2 (0.47) | RNASEH1KDM4AKDM5AKDM5BMAPT | |
| SCHEMBL7682574 | 0.72 | KDM4A (0.43) | RNASEH1KDM4AKDM5AKDM5BHAO1 | |
| SCHEMBL7680945 | 0.72 | PTPRC (0.44) | RNASEH1KDM4AKDM5AKDM5BMAPT | |
| SCHEMBL7076761 | 0.72 | MCL1 (0.48) | RNASEH1KDM4AKDM5AKDM5BMAPT | |
| SCHEMBL7074236 | 0.70 | POLB (0.47) | POLB | |
| SCHEMBL8089595 | 0.69 | MAPT (0.46) | MAPTTP53ALDH1A1POLBALOX15 | |
| Ethyne SCHEMBL7605585 | 0.68 | GPR17 (0.45) | RNASEH1KDM4AKDM5AKDM5BGPR17 | |
| SCHEMBL7592453 | 0.68 | GPR35 (0.43) | RNASEH1NPSR1GPR17 | |
| SCHEMBL7072708 | 0.68 | GPR17 (0.61) | MAPTALDH1A1POLBALOX15HSD17B10 | |
| SCHEMBL27873446 | 0.67 | PTPRG (0.56) | RNASEH1KDM4AKDM5AKDM5BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054667-A1 | BICYCLIC PYRROLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANTIINFLAMMATORY AND IMMUNOMODULATING AGENTS | AstraZeneca UK Limited (GB) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999040913-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA UK LIMITED (GB) | 1999-08-19 | — | — | WO | disclosed |