Acetone

Acetone

SCHEMBL8093753

CC(=O)/C=C/c1cccs1.CC(C)=O

nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 1/20 0.67
LMNA P02545 3/20 0.58
ABCG2 Q9UNQ0 2/20 0.56
SMN1; SMN2 Q16637 4/20 0.54
MAPT P10636 3/20 0.54
ALDH1A1 P00352 2/20 0.54
HPGD P15428 1/20 0.54
NPC1 O15118 2/20 0.53
RAB9A P51151 2/20 0.53
HTT P42858 2/20 0.53
KMT2A Q03164 2/20 0.53
KDM4E B2RXH2 1/20 0.51
MEN1 O00255 1/20 0.51
PSMD14 O00487 1/20 0.51
TP53 P04637 1/20 0.51
GLA P06280 1/20 0.51
TAS1R3 Q7RTX0 1/20 0.51
TAS1R1 Q7RTX1 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetone SCHEMBL8093756 1.00 HCAR2 (0.67) HCAR2LMNAABCG2SMN1; SMN2MAPT
SCHEMBL369705 0.98 HCAR2 (0.69) HCAR2LMNAABCG2SMN1; SMN2MAPT
SCHEMBL1862223 0.98 HCAR2 (0.69) HCAR2LMNAABCG2SMN1; SMN2MAPT
SCHEMBL5598741 0.82 HCAR2 (0.74) HCAR2LMNAABCG2SMN1; SMN2MAPT
SCHEMBL5598744 0.82 HCAR2 (0.74) HCAR2LMNAABCG2SMN1; SMN2MAPT
SCHEMBL143282 0.80 HCAR2 (1.00) HCAR2LMNAABCG2SMN1; SMN2MAPT
SCHEMBL600082 0.80 HCAR2 (1.00) HCAR2LMNAABCG2SMN1; SMN2MAPT
SCHEMBL4197243 0.80 HCAR2 (0.71) HCAR2LMNAABCG2SMN1; SMN2MAPT
SCHEMBL1086015 0.80 HCAR2 (0.71) HCAR2LMNAABCG2SMN1; SMN2MAPT
SCHEMBL24728234 0.78 HCAR2 (0.58) HCAR2LMNAABCG2SMN1; SMN2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0973936-A1 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC AMINOTHIOETHER ACIDS ELI LILLY AND COMPANY (US) 2000-01-26 EP disclosed
WO-1998046786-A1 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC AMINOTHIOETHER ACIDS ELI LILLY AND COMPANY (US) 1998-10-22 WO disclosed