Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8094065 | 1.00 | LMNA (0.40) | LMNAMAPTAKR1C3AKR1C2AKR1C1 | |
| SCHEMBL5788690 | 0.81 | LTA4H (0.49) | CYP1A2CYP2C19ALDH1A1MEN1KMT2A | |
| SCHEMBL7620158 | 0.79 | TCF4 (0.51) | LMNAMAPTAKR1C3AKR1C2AKR1C1 | |
| SCHEMBL7627953 | 0.79 | TCF4 (0.51) | LMNAMAPTAKR1C3AKR1C2AKR1C1 | |
| SCHEMBL7620156 | 0.79 | TCF4 (0.51) | LMNAMAPTAKR1C3AKR1C2AKR1C1 | |
| SCHEMBL8094069 | 0.70 | DAO (0.38) | CYP1A2CYP2C19MEN1KMT2A | |
| SCHEMBL6050656 | 0.70 | CES2 (0.67) | LMNAMAPTALDH1A1MAPK1PLK1 | |
| SCHEMBL4030308 | 0.70 | LTA4H (0.53) | LMNAMAPTCYP1A2ALDH1A1MAPK1 | |
| SCHEMBL8985444 | 0.70 | TCF4 (0.38) | MAPTAKR1C3AKR1C2AKR1C1CYP1A2 | |
| SCHEMBL8985441 | 0.70 | TCF4 (0.38) | MAPTAKR1C3AKR1C2AKR1C1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808304-B1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2000-12-27 | — | — | EP | disclosed |
| US-5916905-A | ANTIARTHRITIC AGENTS; ANALGESICS; ANTIPYRETICS | G. D. SEARLE & CO. (US) | 1999-06-29 | — | — | US | disclosed |
| US-5686470-A | 2, 3-substituted pyridines for the treatment of inflammation | WEIER RICHARD M (US) | 1997-11-11 | — | — | US | disclosed |